Biological study of a nontoxic, water-soluble immunoadjuvant from mycobacterial cell walls.
نویسندگان
چکیده
Whole mycobacterial cells, which are used in Freund's complete adjuvant, besides inducing hypersensitivity to tuberculoprotein, also can elicit hyperreactivity to endotoxins, lymphoid hyperplasia, and allergic polyarthritis in rats. The data reported here demonstrate that a potent water-soluble adjuvant obtained from mycobacterial cell walls is also effective in increasing the immune response to viruses, and that it is free of the toxic effects observed with whole mycobacterial cells.
منابع مشابه
Water-soluble adjuvants prepared from Mycobacterium smegmatis and human mixed mycobacteria strains C, DT, and PN were found to increase lymphocyte response in one-way mixed-lymphocyte culture and in vitro immuniza
WSA2 from mycobacteria have recently been shown to have potent biological activity ( I , 2, 5). These adjuvants are nontoxic in vitro and may prove useful in amplification of the immune response. Adam et a!. ( 1) reported that water-soluble fractions that were extracted from the myco bacterial cell walls were nontoxic and were capable of increasing circulating antibodies and of inducing delayed...
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 69 4 شماره
صفحات -
تاریخ انتشار 1972